Nanotoxicological study of polyol-made cobalt-zinc ferrite nanoparticles in rabbit.
Identifieur interne : 000021 ( Main/Exploration ); précédent : 000020; suivant : 000022Nanotoxicological study of polyol-made cobalt-zinc ferrite nanoparticles in rabbit.
Auteurs : Amel Hanini [France] ; Mohamed El Massoudi [Tunisie] ; Julie Gavard [France] ; Kamel Kacem [Tunisie] ; Souad Ammar [France] ; Ouajdi Souilem [Tunisie]Source :
- Environmental toxicology and pharmacology [ 1872-7077 ] ; 2016.
Abstract
The increasing use of engineered nanomaterials in commercial manufacturing and consumer products presents an important toxicological concern. Superparamagnetic zinc-cobalt ferrite nanoparticles (SFN) emerge as a promising tool for early cancer diagnostics and targeted therapy. However, toxicity and biological activities of SFN should be evaluated in vitro and in vivo in animal before any clinical application. In this study we aim to synthesize and characterize such objects using polyol process in order to assess its nanotoxicological profile in vitro as well as in vivo. The produced particles consist of a cobalt-zinc ferrite phase corresponding to the Zn0.8Co0.2Fe2O4 composition. They are isotropic in shape single crystals of 8nm in size. The thermal variation of their dc-magnetization confirms their superparamagnetic behavior. In vitro, acute exposure (4h) to them (100μgmL(-1)) induced an important decrease of healthy Human Umbilical Vein Endothelial Cells (HUVECs) viability. In vivo investigation in New-Zealand rabbits revealed that they lead to tissue toxicities; in lungs, liver and kidneys. Our investigations report, for the first time as far as we know, that SFN exhibit harmful properties in human cells and mammals.
DOI: 10.1016/j.etap.2016.06.010
PubMed: 27375215
Affiliations:
- France, Tunisie
- Gouvernorat de La Manouba, Île-de-France
- La Manouba, Paris
- Université Paris-Descartes, Université de la Manouba
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Superparamagnetic zinc-cobalt ferrite nanoparticles (SFN) emerge as a promising tool for early cancer diagnostics and targeted therapy. However, toxicity and biological activities of SFN should be evaluated in vitro and in vivo in animal before any clinical application. In this study we aim to synthesize and characterize such objects using polyol process in order to assess its nanotoxicological profile in vitro as well as in vivo. The produced particles consist of a cobalt-zinc ferrite phase corresponding to the Zn0.8Co0.2Fe2O4 composition. They are isotropic in shape single crystals of 8nm in size. The thermal variation of their dc-magnetization confirms their superparamagnetic behavior. In vitro, acute exposure (4h) to them (100μgmL(-1)) induced an important decrease of healthy Human Umbilical Vein Endothelial Cells (HUVECs) viability. In vivo investigation in New-Zealand rabbits revealed that they lead to tissue toxicities; in lungs, liver and kidneys. Our investigations report, for the first time as far as we know, that SFN exhibit harmful properties in human cells and mammals.</div></front></TEI><affiliations><list><country><li>France</li><li>Tunisie</li></country><region><li>Gouvernorat de La Manouba</li><li>Île-de-France</li></region><settlement><li>La Manouba</li><li>Paris</li></settlement><orgName><li>Université Paris-Descartes</li><li>Université de la Manouba</li></orgName></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Hanini, Amel" sort="Hanini, Amel" uniqKey="Hanini A" first="Amel" last="Hanini">Amel Hanini</name></region><name sortKey="Ammar, Souad" sort="Ammar, Souad" uniqKey="Ammar S" first="Souad" last="Ammar">Souad Ammar</name><name sortKey="Gavard, Julie" sort="Gavard, Julie" uniqKey="Gavard J" first="Julie" last="Gavard">Julie Gavard</name></country><country name="Tunisie"><region name="Gouvernorat de La Manouba"><name sortKey="Massoudi, Mohamed El" sort="Massoudi, Mohamed El" uniqKey="Massoudi M" first="Mohamed El" last="Massoudi">Mohamed El Massoudi</name></region><name sortKey="Kacem, Kamel" sort="Kacem, Kamel" uniqKey="Kacem K" first="Kamel" last="Kacem">Kamel Kacem</name><name sortKey="Souilem, Ouajdi" sort="Souilem, Ouajdi" uniqKey="Souilem O" first="Ouajdi" last="Souilem">Ouajdi Souilem</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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